Publications

Full publications can be found through:

• Google scholar profile 

• NCBI pubmed link

Publications

Please contact me for any reprints. Last updated March 2024

• The many faces of Candida auris: Phenotypic and strain variation in an emerging pathogen. Darian J Santana, Guolei Zhao, Teresa R O'Meara. PLoS Pathogens. March 2024, PMID: 38427609

• CryptoCEN: A Co-Expression Network for Cryptococcus neoformans reveals novel proteins involved in DNA damage repair. Matthew J. O’Meara ,Jackson R. Rapala, Connie B. Nichols, A. Christina Alexandre, R. Blake Billmyre, Jacob L Steenwyk, J. Andrew Alspaugh, Teresa R. O’Meara . PLoS Genetics. February 15, 2024 PMID: 38359090

• A Candida auris-specific adhesin, Scf1, governs surface association, colonization, and virulence. Santana, Darian J.; Anku, Juliet A. E.; Zhao, Guolei; Zarnowski, Robert; Johnson, Chad J.; Hautau, Haley; Visser, Noelle D.; Ibrahim, Ashraf S.; Andes, David; Nett, Jeniel E.; Singh, Shakti; O'Meara, Teresa R. Science September 2023 PMID: 37769084 

• Imaging-Based Screening Identifies Modulators of the eIF3 Translation Initiation Factor Complex in Candida albicans. Metzner KM, O'Meara MJ, Halligan B, Wotring J, Sexton JZ, O'Meara TR. Antimicrobial Agents and Chemotherapy June 2023 PMID: 37382550 

• Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease. Anderson FM, Visser ND, Amses KR, Hodgins-Davis A, Weber AM, Metzner KM, McFadden MJ, Mills RE, O'Meara MJ, James TY, O'Meara TR. PLoS Biology May 2023 PMID: 37205709 

• Forward and Reverse Genetic Dissection of Morphogenesis Identifies Filament-Competent Candida auris Strains. Santana DS and O'Meara TR.  Nature Communications Dec 2021, DOI 

• Adaptive immunity induces mutualism between commensal eukaryotes. Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. Nature. 2021 PMID: 34262174.

• Metagenomic Sequencing for Direct Identification of Candida auris Colonization. O'Meara TR.  mSphere. 2021 PMID: 34346707

• Germination of a field: Women in Candida albicans research. Anderson FM, Polvi EJ, Veri AO, O'Meara TR. Current Clinical Microbiology Reports May 2021, DOI 

• DeORFanizing Candida albicans Genes using Coexpression. O'Meara TR, O'Meara MJ. mSphere January 2021. PMID:  33472984

• Monitoring Inflammasome Priming and Activation in Response to Candida albicans Santana DJ, Anderson FM, O'Meara TR.  Current Protocols in Microbiology December 2020 PMID: 33108055

• Systems Biology of Host-Candida interactions: Understanding How We Shape Each Other. Hodgins-Davis A, O’Meara TR. Current Opinions in Microbiology May 30;58:1-7. 2020 PMID: 32485592 (Review)

• Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19. Mirabelli C, Wotring JW, Zhang CJ, McCarty SM, Fursmidt R, Pretto CD, Qiao Y, Zhang Y, Frum T, Kadambi NS, Amin AT, O'Meara TR, Spence JR, Huang J, Alysandratos KD, Kotton DN, Handelman SK, Wobus CE, Weatherwax KJ, Mashour GA, O'Meara MJ, Chinnaiyan AM, Sexton JZ. Proc Natl Acad Sci U S A. 2021 PMID: 34413211.

• Reengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability. Hettiaratchi MH, O’Meara MJ, O’Meara TR, Pickering AJ, Letko-Khait N, Shoichet MS. Science Advances 2020. PMID: 32875119

Selected postdoctoral work:

• Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen. O’Meara TR, O’Meara MJ, Polvi EJ, Pourhaghighi MR, Liston SD, Lin Z-Y, Veri AO, Emili A, Gingras A-C, Cowen LE.  PLoS Biology Jul 8;17(7):e3000358. 2019. PMID: 31283755

• mSphere of Influence: Start with an Interesting Biological Phenomenon. O’Meara T.  mSphere. Jun 19;4(3). 2019 PMID: 31217302 (Review)

• Insights into the host-pathogen interaction: C. albicans manipulation of macrophage pyroptosis. O’Meara TR and Cowen LE. Microbial Cell 12;5(12):566-568. 2018 PMID: 30533421 (Review)

• High-throughput screening identifies genes required for fungal induction of macrophage pyroptosis. O’Meara TR, Duah K, Guo CX, Maxson ME, Gaudet R, Koselny K, Wellington M, Powers ME, MacAlpine J, O’Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen S, Cowen LE.  MBio. 21;9(4),  2018 PMID: 30131363 

• The Hsp90 chaperone network modulates Candida virulence traits. O’Meara TR, Robbins N, and and Cowen LE.  Trends in Microbiology, 25(10):809-81,9 2017. PMID: 28549824 (Review)

•  Mapping the Hsp90 genetic network reveals ergosterol biosynthesis and phosphatidylinositol-4-kinase signaling as core circuitry governing cellular stress. O'Meara TR, Veri AO*, Polvi EJ*, Li X*, Valaei SF, Diezmann S, Cowen LE. PLoS Genetics 12(6):e1006142, 2016. PMID: 27341673 (*contributed equally) (Highlighted in F1000)

• Global analysis of fungal morphology exposes mechanisms of host cell escape. O’Meara TR*, Veri AO*, Ketela T, Jiang B, Roemer T, Cowen LE.  Nature Communications 6:6741, 2015. PMID: 25824284 (*contributed equally)

•  Hsp90-dependent regulatory circuitry controlling temperature-dependent fungal development and virulence. O’Meara TR and Cowen LE. Cellular Microbiology 2014. PMID: 24438186 (Review, Highlighted in F1000)

Selected graduate work:

• The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host. O'Meara TR, Xu W, Selvig KM, O'Meara MJ, Mitchell AP, Alspaugh JA. Molecular and Cellular Biology 34(4):673-84, 2014. PMID: 24324006 (Highlighted in F1000)

• Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of host immune responses. O'Meara TR, Holmer SM, Selvig K, Dietrich F, Alspaugh JA.  MBio 4(1), 2013. PMID 23322637  (Highlighted in F1000)

• The Cryptococcus neoformans capsule: a sword and a shield. O'Meara TR, Alspaugh JA. Clinical Microbiology Reviews 25(3):87-408, 2012. PMID 22763631 (Review)

•  Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule. O'Meara TR, Norton D, Price MS, Hay C, Clements MF, Nichols CB, Alspaugh JA. PLoS Pathogens 6(2):e1000776, 2010. PMID 20174553

•  Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. O'Meara TR, Hay C, Price MS, Giles S, Alspaugh JA. Eukaryotic Cell 9(8):1193-202, 2010. PMID 20581290.